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Article

TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy.

Acta neuropathologica communications - 22 Apr 2016

Munch-Petersen Helga D, Asmar Fazila, Dimopoulos Konstantinos, Areškevičiūtė Aušrinė, Brown Peter, Girkov Mia Seremet, Pedersen Anja, Sjö Lene D, Heegaard Steffen, Broholm Helle, Kristensen Lasse S, Ralfkiaer Elisabeth, Grønbæk Kirsten

Abstract excerpt

Primary central nervous system lymphoma (PCNSL) is an aggressive variant of diffuse large B-cell lymphoma (DLBCL) confined to the CNS. TP53 mutations (MUT-TP53) were investigated in the context of MIR34A/B/C- and DAPK promoter methylation status, and associated with clinical outcomes in PCNSL patients. In a total of 107 PCNSL patients clinical data were recorded, histopathology reassessed, and genetic and...

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Identifiers

PMID: 27101868
DOI: 10.1186/s40478-016-0307-6
PMCID: PMC4840983

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Source receipt: pubmed, retrieved 7 Sept 2026.

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