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Article

PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma.

PloS one - 1 Jan 2016

Chowdhury Basudev, Porter Elizabeth G, Stewart Jane C, Ferreira Christina R, Schipma Matthew J, Dykhuizen Emily C

Abstract excerpt

Polybromo-1 (PBRM1) is a component of the PBAF (Polybromo-associated-BRG1- or BRM-associated factors) chromatin remodeling complex and is the second most frequently mutated gene in clear-cell renal cell Carcinoma (ccRCC). Mutation of PBRM1 is believed to be an early event in carcinogenesis, however its function as a tumor suppressor is not understood. In this study, we have employed Next Generation Sequencing to...

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Identifiers

PMID: 27100670
DOI: 10.1371/journal.pone.0153718
PMCID: PMC4839679

Genes

PBRM1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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