Article
Allele-Skewed DNA Modification in the Brain: Relevance to a Schizophrenia GWAS.
American journal of human genetics - 5 May 2016
Gagliano Sarah A, Ptak Carolyn, Mak Denise Y F, Shamsi Mehrdad, Oh Gabriel, Knight Joanne, Boutros Paul C, Petronis Arturas
Abstract excerpt
Numerous recent studies have suggested that phenotypic effects of DNA sequence variants can be mediated or modulated by their epigenetic marks, such as allele-skewed DNA modification (ASM). Using Affymetrix SNP microarrays, we performed a comprehensive search of ASM effects in human post-mortem brain and sperm samples (total n = 256) from individuals with major psychosis and control individuals. Depending on the...
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