Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AIP mutations impair AhR signaling in pituitary adenoma patients fibroblasts and in GH3 cells.

Endocrine-related cancer - 1 May 2016

Lecoq Anne-Lise, Viengchareun Say, Hage Mirella, Bouligand Jérôme, Young Jacques, Boutron Audrey, Zizzari Philippe, Lombès Marc, Chanson Philippe, Kamenický Peter

Abstract excerpt

Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene predispose humans to pituitary adenomas through unknown molecular mechanisms. The best-known interacting partner of AIP is the aryl hydrocarbon receptor (AhR), a transcription factor that mediates the effects of xenobiotics implicated in carcinogenesis. As 75% of AIP mutations disrupt the physical and/or functional interaction with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Cytochrome P-450 CYP1B1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Intracellular Signaling Peptides and Proteins

Share to Pituitary Neoplasms

Share to Receptors, Aryl Hydrocarbon

Share to Repressor Proteins

Source

Identifiers

PMID: 27080473
DOI: 10.1530/ERC-16-0041

Genes

AIP
AHRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AIP mutations impair AhR signaling in pituitary adenoma patients fibroblasts and in GH3 cells.PMID 27080473Read ↗

The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas.Semantic proximity Read ↗

The Role of the Aryl Hydrocarbon Receptor-Interacting Protein Gene in Familial and Sporadic Pituitary AdenomasSemantic proximity Read ↗

Molecular genetics of the aip gene in familial pituitary tumorigenesis.Semantic proximity Read ↗

Familial isolated pituitary adenoma is independent of Ahr genotype in a novel mouse model of diseaseSemantic proximity Read ↗

Familial Isolated Pituitary Adenomas (FIPA) and Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) GeneSemantic proximity Read ↗

Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications.Semantic proximity Read ↗

Variable pathological and clinical features of a large Brazilian family harboring a mutation in the aryl hydrocarbon receptor-interacting protein geneSemantic proximity Read ↗

Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families.Semantic proximity Read ↗

Aryl hydrocarbon receptor-interacting protein and acromegaly.Semantic proximity Read ↗

Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations.Semantic proximity Read ↗

Anterior pituitary adenomas: inherited syndromes, novel genes and molecular pathwaysSemantic proximity Read ↗

Acromegaly, genetic variants of the aryl hydrocarbon receptor pathway and environmental burden.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.