Article
The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.
Journal of Alzheimer's disease : JAD - 15 Apr 2016
Berger Miles, Nadler Jacob W, Friedman Allan, McDonagh David L, Bennett Ellen R, Cooter Mary, Qi Wenjing, Laskowitz Daniel T, Ponnusamy Vikram, Newman Mark F, Shaw Leslie M, Warner David S, Mathew Joseph P, James Michael L
Abstract excerpt
BACKGROUND: Preclinical studies have found differential effects of isoflurane and propofol on the Alzheimer's disease (AD)-associated markers tau, phosphorylated tau (p-tau) and amyloid-β (Aβ). OBJECTIVE: We asked whether isoflurane and propofol have differential effects on the tau/Aβ ratio (the primary outcome), and individual AD biomarkers. We also examined whether genetic/intraoperative factors influenced...
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