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Article

Variability of CSF Alzheimer’s Disease Biomarkers: Implications for Clinical Practice

24 Jun 2014

Abstract excerpt

BACKGROUND: Cerebrospinal fluid (CSF) biomarkers are increasingly being used for diagnosis of Alzheimer's disease (AD). OBJECTIVE: We investigated the influence of CSF intralaboratory and interlaboratory variability on diagnostic CSF-based AD classification of subjects and identified causes of this variation. METHODS: We measured CSF amyloid-β (Aβ) 1-42, total tau (t-tau), and phosphorylated tau (p-tau) by...

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PMID: 24959687
DOI: 10.1371/journal.pone.0100784

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