Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the mechanism of non-small-cell lung cancer cell lines resistant to epidermal growth factor receptor tyrosine kinase inhibitor.

Journal of cancer research and therapeutics - 1 Jan 2000

Yu Yongkang, Luo Yaohui, Zheng Yifeng, Zheng Xiushan, Li Wei, Yang Lie, Jiang Jianqing

Abstract excerpt

PURPOSE: Here we aimed to explore the possible mechanism and potential regulatory relationships in which the non.small.cell lung cancer. (NSCLC)-resisted epidermal growth factor receptor. (EGFR) tyrosine kinase inhibitor erlotinib. MATERIALS AND METHODS: GSE38310, the gene expression profiles of NSCLC cell lines treated with dimethylsulfoxide or erlotinib, including HCC827, ER3, and T15-2, were downloaded from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Neoplasm
Share to Early Growth Response Protein 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erlotinib Hydrochloride

Share to Neoplasm Proteins

Share to SOX9 Transcription Factor

Share to STAT3 Transcription Factor

Share to STAT5 Transcription Factor

Share to STAT6 Transcription Factor

Source

Identifiers

PMID: 27072223
DOI: 10.4103/0973-1482.151425

Genes

SOX9
STAT3
EGR1
STAT6
EGFR
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the mechanism of non-small-cell lung cancer cell lines resistant to epidermal growth factor receptor tyrosine kinase inhibitor.PMID 27072223Read ↗

EREG increases stemness associated genes expression and promotes Chemoresistance of non-small cell lung cancer via ERK signalingSemantic proximity Read ↗

Identification of biomarkers, pathways and potential therapeutic targets for EGFR-TKI resistance in non-small-cell lung cancerSemantic proximity Read ↗

Exploring the mechanism of prognostic genes associated with neuroendocrine differentiation and immunotherapy resistance in non-small cell lung cancer based on the bulk transcriptome and single cell RNA sequencingSemantic proximity Read ↗

Microarray expression profile of long non-coding RNAs in EGFR-TKIs resistance of human non-small cell lung cancerSemantic proximity Read ↗

Identification of MMP1 as a potential gene conferring erlotinib resistance in non-small cell lung cancer based on bioinformatics analyses.Semantic proximity Read ↗

Mechanisms analysis for Formononetin counteracted-Osimertinib resistance in Non-small-cell lung cancer cells: from the insight into the gene transcriptional levelSemantic proximity Read ↗

Epiregulin increases stemness-associated genes expression and promotes chemoresistance of non-small cell lung cancer via ERK signalingSemantic proximity Read ↗

Whole exome analysis reveals the genomic profiling related to chemo-resistance in Chinese population with limited-disease small cell lung cancer.Semantic proximity Read ↗

Regulatory Network Analysis to Reveal Important miRNAs and Genes in Non-Small Cell Lung Cancer.Semantic proximity Read ↗

[Molecular mechanism of erlotinib resistance in epidermal growth factor receptor mutant non-small cell lung cancer cell line H1650].Semantic proximity Read ↗

Activation of NF-κB/ALDH1A1 Signaling Promotes Non-Mutational Resistance to EGFR-TKIs in Non-Small Cell Lung CancerSemantic proximity Read ↗

Network-based Identification of Key Proteins and Repositioning of Drugs for Non-Small Cell Lung CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.