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Article

Heterogeneity and Clinical Effect of Epidermal Growth Factor Receptor in Primary Lung and Brain Metastases of Nonsmall Cell Lung Cancer.

The Journal of surgical research - 1 Mar 2023

Xu Shuonan, Zhu Jianfei, Zhong Daixing, Wang Wenchen, Wen Yinsheng, Zhang Lanjun, Jiang Tao

Abstract excerpt

INTRODUCTION: This study aimed to analyze the heterogeneity in epidermal growth factor receptor (EGFR) gene mutation and its impact on clinical outcomes in primary tumor and corresponding brain metastasis (BM) in nonsmall cell lung cancer (NSCLC). MATERIALS AND METHODS: Primary pulmonary tumors and paired BMs of 27 NSCLC patients were surgically removed. All brain lesions were histologically confirmed as...

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PMID: 36459860
DOI: 10.1016/j.jss.2022.10.066

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