Article
Polymorphisms within base and nucleotide excision repair pathways and risk of differentiated thyroid carcinoma.
DNA repair - 1 May 2016
Cipollini Monica, Figlioli Gisella, Maccari Giuseppe, Garritano Sonia, De Santi Chiara, Melaiu Ombretta, Barone Elisa, Bambi Franco, Ermini Stefano, Pellegrini Giovanni, Cristaudo Alfonso, Foddis Rudy, Bonotti Alessandra, Romei Cristina, Vivaldi Agnese, Agate Laura, Molinari Eleonora, Barale Roberto, Forsti Asta, Hemminki Kari, Elisei Rossella, Gemignani Federica, Landi Stefano
Abstract excerpt
The thyrocytes are exposed to high levels of oxidative stress which could induce DNA damages. Base excision repair (BER) is one of the principal mechanisms of defense against oxidative DNA damage, however recent evidences suggest that also nucleotide excision repair (NER) could be involved. The aim of present work was to identify novel differentiated thyroid cancer (DTC) risk variants in BER and NER genes. For...
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