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Article

Oxidative DNA damage and DNA repair gene variants in differentiated thyroid cancer patients treated with radioactive iodine.

Endocrine - 1 Sept 2025

Avsar Fevzi Necati, Abbasoğlu Semra Doğru, Ademoğlu Evin, Sahutoglu Tuncay

Abstract excerpt

PURPOSE: This study aimed to evaluate oxidative DNA damage and its association with polymorphisms in DNA repair enzymes among patients with differentiated thyroid cancer (DTC) treated with high-dose radioactive iodine (RAI, ≥100 mCi). Relationships between DNA damage markers, gene variants, and clinical or tumor characteristics were also explored. METHODS: Seventy-nine patients with DTC and 59 age and sex matched...

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Identifiers

PMID: 40418522
DOI: 10.1007/s12020-025-04288-7
PMCID: PMC12370813

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