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Article

Differential regulation of miR-146a/FAS and miR-21/FASLG axes in autoimmune lymphoproliferative syndrome due to FAS mutation (ALPS-FAS).

Clinical and experimental immunology - 1 Aug 2016

Marega Lia Furlaneto, Teocchi Marcelo Ananias, Dos Santos Vilela Maria Marluce

Abstract excerpt

Most cases of autoimmune lymphoproliferative syndrome (ALPS) have an inherited genetic defect involving apoptosis-related genes of the FAS pathway. MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs playing a role in the control of gene expression. This is the first report on miRNAs in ALPS patients. We studied a mother and son carrying the same FAS cell surface death receptor (FAS) mutation, but...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27060458
DOI: 10.1111/cei.12800
PMCID: PMC4954998

Genes

FAS
FASLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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