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Article

Internal Duplications of DH, JH, and C Region Genes Create an Unusual IgH Gene Locus in Cattle

7 Apr 2016

Abstract excerpt

It has been suspected for many years that cattle possess two functional IgH gene loci, located on Bos taurus autosome (BTA) 21 and BTA11, respectively. In this study, based on fluorescence in situ hybridization and additional experiments, we showed that all functional bovine IgH genes were located on BTA21, and only a truncated μCH2 exon was present on BTA11. By sequencing of seven bacterial artificial chromosome...

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PMID: 27053761
DOI: 10.4049/jimmunol.1600158

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