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Article

Defects of WFS1-mediated peptide hormones secretion contribute to the manifestations of Wolfram syndrome.

Life sciences - 15 Dec 2024

Li Suli, Wang Linlin, Li Yunfei, Hu Liqiao, Guo Yanying, Li Zonghong

Abstract excerpt

AIMS: The study aims to investigate whether WFS1 is involved in the regulation of the exportation and secretion of other peptide hormones, as well as to elucidate the precise molecular mechanisms underlying WS caused by pathogenic mutations in the WFS1 gene. MATERIALS AND METHODS: The plasma proteome from the WS patients (n = 2, male) and WFS1-deficient mice (n = 5, male) were analyzed using liquid-chromatography...

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Identifiers

PMID: 39510168
DOI: 10.1016/j.lfs.2024.123219

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