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Article

Impact of Ser17 Phosphorylation on the Conformational Dynamics of the Oncoprotein MDM2.

Biochemistry - 3 May 2016

Bueren-Calabuig Juan A, Michel Julien

Abstract excerpt

MDM2 is an important oncoprotein that downregulates the activity of the tumor suppressor protein p53 via binding of its N-terminal domain to the p53 transactivation domain. The first 24 residues of the MDM2 N-terminal domain form an intrinsically disordered "lid" region that interconverts on a millisecond time scale between "open" and "closed" states in unliganded MDM2. While the former conformational state is...

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Source

Identifiers

PMID: 27050388
DOI: 10.1021/acs.biochem.6b00127

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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