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Article

Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis.

Oncotarget - 26 Apr 2016

Seidel Philipp, Remus Martina, Delacher Michael, Grigaravicius Paulius, Reuss David E, Frappart Lucien, von Deimling Andreas, Feuerer Markus, Abdollahi Amir, Frappart Pierre-Olivier

Abstract excerpt

Nijmegen Breakage Syndrome is a disease caused by NBN mutations. Here, we report a novel function of Nbn in skin homeostasis. We found that Nbn deficiency in hair follicle (HF) progenitors promoted increased DNA damage signaling, stimulating p16Ink4a up-regulation, Trp53 stabilization and cytokines secretion leading to HF-growth arrest and hair loss. At later stages, the basal keratinocytes layer exhibited also...

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Source

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Identifiers

PMID: 27050272
DOI: 10.18632/oncotarget.8470
PMCID: PMC5029606

Genes

NBN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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