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Article

Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction.

Biochimica et biophysica acta - 1 Aug 2016

Kokoszka Jason E, Waymire Katrina G, Flierl Adrian, Sweeney Katelyn M, Angelin Alessia, MacGregor Grant R, Wallace Douglas C

Abstract excerpt

The mouse fetal and adult hearts express two adenine nucleotide translocator (ANT) isoform genes. The predominant isoform is the heart-muscle-brain ANT-isoform gene 1 (Ant1) while the other is the systemic Ant2 gene. Genetic inactivation of the Ant1 gene does not impair fetal development but results in hypertrophic cardiomyopathy in postnatal mice. Using a knockin X-linked Ant2 allele in which exons 3 and 4 are...

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Identifiers

PMID: 27048932
DOI: 10.1016/j.bbabio.2016.03.026
PMCID: PMC5100012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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