Article
Long-read sequence assembly of the gorilla genome.
Science (New York, N.Y.) - 1 Apr 2016
Gordon David, Huddleston John, Chaisson Mark J P, Hill Christopher M, Kronenberg Zev N, Munson Katherine M, Malig Maika, Raja Archana, Fiddes Ian, Hillier LaDeana W, Dunn Christopher, Baker Carl, Armstrong Joel, Diekhans Mark, Paten Benedict, Shendure Jay, Wilson Richard K, Haussler David, Chin Chen-Shan, Eichler Evan E
Abstract excerpt
Accurate sequence and assembly of genomes is a critical first step for studies of genetic variation. We generated a high-quality assembly of the gorilla genome using single-molecule, real-time sequence technology and a string graph de novo assembly algorithm. The new assembly improves contiguity by two to three orders of magnitude with respect to previously released assemblies, recovering 87% of missing reference...
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