Article
Estrogen Receptor Expression Is Associated with DNA Repair Capacity in Breast Cancer.
PloS one - 1 Jan 2016
Matta Jaime, Morales Luisa, Ortiz Carmen, Adams Damian, Vargas Wanda, Casbas Patricia, Dutil Julie, Echenique Miguel, Suárez Erick
Abstract excerpt
Estrogen-receptor-positive (ER+) tumors employ complex signaling that engages in crosstalk with multiple pathways through genomic and non-genomic regulation. A greater understanding of these pathways is important for developing improved biomarkers that can better determine treatment choices, risk of recurrence and cancer progression. Deficiencies in DNA repair capacity (DRC) is a hallmark of breast cancer (BC);...
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