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Article

Three dimensional imaging of the intracellular assembly of a functional viral RNA replicase complex

1 Jan 2016

Abstract excerpt

Positive-strand RNA viruses, which can be devastating pathogens in humans, animals and plants, replicate their genomes on intracellular membranes. Here, we describe the three-dimensional ultrastructural organization of a tombusvirus replicase in yeast, a valuable model for exploring virus-host interactions. We visualized the intracellular distribution of a viral replicase protein using metal-tagging transmission...

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PMID: 27026525
DOI: 10.1242/jcs.181586

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