Article
CaMKK2 Expression Correlates with High-Risk CLL Biology, and Pharmacologic Inhibition Is Associated with Reduced Leukemic Cell Survival and Nurse-like Cell Support In Vitro.
Cells - 20 Jul 2026
Jauhari Shekeab, Cooper-Volkheimer Alicia D, Verma Vini, Kaplan Dilber Gökçe, Basher Fahmin, Weinberg J Brice, Chao Nelson J, Racioppi Luigi
Abstract excerpt
BACKGROUND/OBJECTIVES: Chronic lymphocytic leukemia (CLL) is characterized by clinical and biological heterogeneity shaped by intrinsic signaling programs and microenvironmental interactions. Established biomarkers, including IGHV mutation status and TP53 alterations, provide important clinical and molecular information, but do not fully capture the diversity of pathways that sustain leukemic cell fitness....
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