SNPs associated with activity and toxicity of cabazitaxel in patients with advanced urothelial cell carcinoma.

doi:10.2217/pgs.15.186

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Article

SNPs associated with activity and toxicity of cabazitaxel in patients with advanced urothelial cell carcinoma.

Pharmacogenomics - 1 Apr 2016

Duran Ignacio, Hagen Carlos, Arranz José Ángel, Apellaniz-Ruiz María, Pérez-Valderrama Begoña, Sala Nuria, Lainez Nuria, García-Del Muro Xavier, Noguerón Esther, Climent Miguel Ángel, Maroto Pablo, Font Albert, García-Donas Jesús, Gallardo Enrique, López-Criado Pilar, González Del Alba Aránzazu, Sáez María Isabel, Vázquez Sergio, Luque Raquel, Rodríguez-Antona Cristina

Abstract excerpt

AIM: We aimed to identify SNPs associated with cabazitaxel toxicity and response within a Phase II clinical trial using this compound in advanced transitional cell carcinoma after progression to a platinum-based regimen. PATIENTS & METHODS: Eleven SNPs in CYP3A4, CYP3A5, CYP2C8, ABCB1 and TUBB1 were genotyped in 45 patients. RESULTS: CYP3A5 rs776746 A allele was associated with protection against gastrointestinal...

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PMID: 27020167
DOI: 10.2217/pgs.15.186

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ABCB1
TUBB1

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