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Clinical utility of ABCB1 genotyping for preventing toxicity in treatment with irinotecan.

Pharmacological research - 1 Oct 2018

Salvador-Martín Sara, García-González Xandra, García María I, Blanco Carolina, García-Alfonso Pilar, Robles Luis, Grávalos Cristina, Pachón Vanessa, Longo Federico, Martínez Virginia, Sanjurjo-Sáez María, López-Fernández Luis A

Abstract excerpt

Preventing severe irinotecan-induced adverse reactions would allow us to offer better treatment and improve patients' quality of life. Transporters, metabolizing enzymes, and genes involved in the folate pathway have been associated with irinotecan-induced toxicity. We analyzed 12 polymorphisms in UGT1A1, ABCB1, ABCG2, ABCC4, ABCC5, and MTHFR in 158 patients with metastatic colorectal cancer treated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30213564
DOI: 10.1016/j.phrs.2018.08.026

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