Article
Comparative Genomics of Carriage and Disease Isolates of Streptococcus pneumoniae Serotype 22F Reveals Lineage-Specific Divergence and Niche Adaptation.
Genome biology and evolution - 21 Apr 2016
Cleary David W, Devine Vanessa T, Jefferies Johanna M C, Webb Jeremy S, Bentley Stephen D, Gladstone Rebecca A, Faust Saul N, Clarke Stuart C
Abstract excerpt
Streptococcus pneumoniae is a major cause of meningitis, sepsis, and pneumonia worldwide. Pneumococcal conjugate vaccines have been part of the United Kingdom's childhood immunization program since 2006 and have significantly reduced the incidence of disease due to vaccine efficacy in reducing carriage in the population. Here we isolated two clones of 22F (an emerging serotype of clinical concern, multilocus...
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