Article
Genetic Correction of Induced Pluripotent Stem Cells From a Deaf Patient With MYO7A Mutation Results in Morphologic and Functional Recovery of the Derived Hair Cell-Like Cells.
Stem cells translational medicine - 1 May 2016
Tang Zi-Hua, Chen Jia-Rong, Zheng Jing, Shi Hao-Song, Ding Jie, Qian Xiao-Dan, Zhang Cui, Chen Jian-Ling, Wang Cui-Cui, Li Liang, Chen Jun-Zhen, Yin Shan-Kai, Huang Tao-Sheng, Chen Ping, Guan Min-Xin, Wang Jin-Fu
Abstract excerpt
UNLABELLED: The genetic correction of induced pluripotent stem cells (iPSCs) induced from somatic cells of patients with sensorineural hearing loss (caused by hereditary factors) is a promising method for its treatment. The correction of gene mutations in iPSCs could restore the normal function of cells and provide a rich source of cells for transplantation. In the present study, iPSCs were generated from a deaf...
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