Article

Application of Human Stem Cells to Model Genetic Sensorineural Hearing Loss and Meniere Disease

2023-02-20

Abstract excerpt

Genetic sensorineural hearing loss and Meniere disease have been associated with rare variations in the coding and non-coding region of the human genome. Most of these variants are classified as likely pathogenic or variants of unknown significance and require functional validation in cellular or animal models. Given the difficulties to obtain human samples and the raising concerns about animal experimentation, hu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65aee46d-5510-501e-92f6-6a66a8d22fe7
DOI: 10.20944/preprints202302.0321.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Application of Human Stem Cells to Model Genetic Sensorineural Hearing Loss and Meniere DiseaseDOI 10.20944/preprints202302.0321.v1Read

A Single-Cell Level Comparison of Human Inner Ear Organoids and the Human Cochlea and Vestibular OrgansSemantic proximity Read

Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations.Semantic proximity Read

Hereditary non-syndromic sensorineural hearing loss: transforming silence to sound.Semantic proximity Read

Genetics of Hearing and DeafnessSemantic proximity Read

Generation of inner ear cell types from embryonic stem cells.Semantic proximity Read

Gene therapy for genetic mutations affecting non-sensory cells in the cochlea.Semantic proximity Read

Vestibular and hearing loss in genetic and metabolic disorders.Semantic proximity Read

Genetic disorders of the vestibular system.Semantic proximity Read

Non-syndromic autosomal dominant sensorineural hearing loss: a new field of research.Semantic proximity Read

Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene.Semantic proximity Read

Human Organoids for Rapid Validation of Gene Variants Linked to Cochlear MalformationsSemantic proximity Read

Genetic Correction of Induced Pluripotent Stem Cells From a Deaf Patient With MYO7A Mutation Results in Morphologic and Functional Recovery of the Derived Hair Cell-Like Cells.Semantic proximity Read