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Article

The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea.

Scientific reports - 24 Mar 2016

Wei Shyh-Yuh, Chao Hsiang-Tai, Tu Cheng-Hao, Lin Ming-Wei, Li Wei-Chi, Low Intan, Shen Horng-Der, Chen Li-Fen, Hsieh Jen-Chuen

Abstract excerpt

Primary dysmenorrhea (PDM), menstrual pain without an organic cause, is a prevailing problem in women of reproductive age. We previously reported alterations of structure and functional connectivity (FC) in the periaqueductal gray (PAG) of PDM subjects. Given that the brain derived neurotrophic factor (BDNF) acts as a pain modulator within the PAG and the BDNF Val66Met polymorphism contributes towards...

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Identifiers

PMID: 27010666
DOI: 10.1038/srep23639
PMCID: PMC4806293

Genes

BDNF

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