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Article

Association of brain-derived neurotrophic factor gene Val66Met polymorphism with primary dysmenorrhea.

PloS one - 1 Jan 2014

Lee Lin-Chien, Tu Cheng-Hao, Chen Li-Fen, Shen Horng-Der, Chao Hsiang-Tai, Lin Ming-Wei, Hsieh Jen-Chuen

Abstract excerpt

Primary dysmenorrhea (PDM), the most prevalent menstrual cycle-related problem in women of reproductive age, is associated with negative moods. Whether the menstrual pain and negative moods have a genetic basis remains unknown. Brain-derived neurotrophic factor (BDNF) plays a key role in the production of central sensitization and contributes to chronic pain conditions. BDNF has also been implicated in...

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Identifiers

PMID: 25383981
DOI: 10.1371/journal.pone.0112766
PMCID: PMC4226574

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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