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Article

The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea.

Scientific reports - 6 Jan 2017

Wei Shyh-Yuh, Chen Li-Fen, Lin Ming-Wei, Li Wei-Chi, Low Intan, Yang Ching-Ju, Chao Hsiang-Tai, Hsieh Jen-Chuen

Abstract excerpt

The mu-opioid receptor (OPRM1) A118G polymorphism underpins different pain sensitivity and opioid-analgesic outcome with unclear effect on the descending pain modulatory system (DPMS). Primary dysmenorrhea (PDM), the most prevalent gynecological problem with clear painful and pain free conditions, serves as a good clinical model of spontaneous pain. The objective of this imaging genetics study was therefore to...

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PMID: 28057931
DOI: 10.1038/srep39906
PMCID: PMC5216367

Genes

OPRM1

Variants

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