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Article

Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature.

Protein science : a publication of the Protein Society - 1 Jul 2016

Boucher Jeffrey I, Bolon Daniel N A, Tawfik Dan S

Abstract excerpt

The last decade has seen a growing number of experiments aimed at systematically mapping the effects of mutations in different proteins, and of attempting to correlate their biophysical and biochemical effects with organismal fitness. While insightful, systematic laboratory measurements of fitness effects present challenges and difficulties. Here, we discuss the limitations associated with such measurements, and...

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PMID: 27010590
DOI: 10.1002/pro.2928
PMCID: PMC4918414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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