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Article

Invariant NKT cells require autophagy to coordinate proliferation and survival signals during differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015

Pei Bo, Zhao Meng, Miller Brian C, Véla Jose Luis, Bruinsma Monique W, Virgin Herbert W, Kronenberg Mitchell

Abstract excerpt

Autophagy regulates cell differentiation, proliferation, and survival in multiple cell types, including cells of the immune system. In this study, we examined the effects of a disruption of autophagy on the differentiation of invariant NKT (iNKT) cells. Using mice with a T lymphocyte-specific del...

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Identifiers

PMID: 25926673
DOI: 10.4049/jimmunol.1402154
PMCID: PMC4458460

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25926673-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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