Apoptin Enhances the Oncolytic Properties of Newcastle Disease Virus

doi:10.1159/000328325

Article

Apoptin Enhances the Oncolytic Properties of Newcastle Disease Virus

1 Nov 2011

Abstract excerpt

OBJECTIVE: Naturally occurring strains of Newcastle disease virus (NDV) have demonstrated the potential to kill cancer cells in both preclinical and clinical studies. Previous studies showed that apoptin, the VP3 protein of chicken infectious anemia virus, is a p53-independent, Bcl-2-insensitive apoptotic protein with the ability to specifically induce apoptosis in transformed cells. In this study, we tested the...

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