Article
Single nucleotide polymorphisms in apoptosis pathway are associated with response to imatinib therapy in chronic myeloid leukemia.
Journal of translational medicine - 24 Mar 2016
Zheng Qiaoli, Cao Jiang, Hamad Nada, Kim Hyeoung-Joon, Moon Joon Ho, Sohn Sang Kyun, Jung Chul Won, Lipton Jeffrey H, Kim Dennis Dong Hwan
Abstract excerpt
BACKGROUND: The mechanism of action of imatinib is known to involve the Fas-mediated apoptosis pathway. Consequently inter-individual variations in this apoptosis pathway might be associated with imatinib response or resistance. METHODS: This study attempted to focus on eight genotypes in the apoptosis pathway including FAS (rs1800682, rs2229521, rs2234767 and rs2234978), FASLG (rs763110), CASP10 (),...