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Article

Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.

Cancer research - 15 Dec 2008

Enjuanes Anna, Benavente Yolanda, Bosch Francesc, Martín-Guerrero Idoia, Colomer Dolors, Pérez-Alvarez Susana, Reina Oscar, Ardanaz Maria T, Jares Pedro, García-Orad Africa, Pujana Miguel A, Montserrat Emili, de Sanjosé Silvia, Campo Elias

Abstract excerpt

To identify low-penetrance susceptibility alleles for chronic lymphocytic leukemia (CLL), we performed a case-control study genotyping 768 single-nucleotide polymorphisms (SNP) in 692 cases of CLL and 738 controls. We investigated nonsynonymous SNPs, SNPs with potential functional effect, and tag SNPs in regulatory gene regions in a total of 172 genes involved in cancer biology. After adjustment for multiple...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

Source

Identifiers

PMID: 19074885
DOI: 10.1158/0008-5472.CAN-08-2221

Genes

APAF1
CCR7
CASP8
BAK1
BAX
BCL2
CASP1
CASP10
CASP3
CCL2
CCNH
CXCL12
LTA
TNF

Variants

rs2266690
rs2266690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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