Article
Incorporation of photo-carbon monoxide releasing materials into electrospun scaffolds for vascular tissue engineering.
Biomedical materials (Bristol, England) - 23 Mar 2016
Michael Eden, Abeyrathna Nawodi, Patel Aatish V, Liao Yi, Bashur Chris A
Abstract excerpt
Hyper-proliferation of smooth muscle cells (SMCs) and a reduction in endothelial cell function are reasons for poor patency rates of current tissue engineered small-diameter vascular grafts. The controlled delivery of carbon monoxide (CO), a gasotransmitter involved in cell signaling, could improve vascular cell function in these grafts. Current CO releasing molecules (CORMs) can improve endothelialization of...
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