Article
Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women.
JAMA psychiatry - 1 May 2016
Mehta Divya, Tropf Felix C, Gratten Jacob, Bakshi Andrew, Zhu Zhihong, Bacanu Silviu-Alin, Hemani Gibran, Magnusson Patrik K E, Barban Nicola, Esko Tõnu, Metspalu Andres, Snieder Harold, Mowry Bryan J, Kendler Kenneth S, Yang Jian, Visscher Peter M, McGrath John J, Mills Melinda C, Wray Naomi R, Lee S Hong, Andreassen Ole A, Bramon Elvira, Bruggeman Richard, Buxbaum Joseph D, Cairns Murray J, Cantor Rita M, Cloninger C Robert, Cohen David, Crespo-Facorro Benedicto, Darvasi Ariel, DeLisi Lynn E, Dinan Timothy, Djurovic Srdjan, Donohoe Gary, Drapeau Elodie, Escott-Price Valentina, Freimer Nelson B, Georgieva Lyudmila, de Haan Lieuwe, Henskens Frans A, Joa Inge, Julià Antonio, Khrunin Andrey, Lerer Bernard, Limborska Svetlana, Loughland Carmel M, Macek Milan, Magnusson Patrik K E, Marsal Sara, McCarley Robert W, McIntosh Andrew M, McQuillin Andrew, Melegh Bela, Michie Patricia T, Morris Derek W, Murphy Kieran C, Myin-Germeys Inez, Olincy Ann, Van Os Jim, Pantelis Christos, Posthuma Danielle, Quested Digby, Schall Ulrich, Scott Rodney J, Seidman Larry J, Toncheva Draga, Tooney Paul A, Waddington John, Weinberger Daniel R, Weiser Mark, Wu Jing Qin
Abstract excerpt
IMPORTANCE: A recently published study of national data by McGrath et al in 2014 showed increased risk of schizophrenia (SCZ) in offspring associated with both early and delayed parental age, consistent with a U-shaped relationship. However, it remains unclear if the risk to the child is due to psychosocial factors associated with parental age or if those at higher risk for SCZ tend to have children at an earlier...
Read the complete abstract on PubMed