Article
Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer-Combined Analysis of the PORTEC Cohorts.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2016
Stelloo Ellen, Nout Remi A, Osse Elisabeth M, Jürgenliemk-Schulz Ina J, Jobsen Jan J, Lutgens Ludy C, van der Steen-Banasik Elzbieta M, Nijman Hans W, Putter Hein, Bosse Tjalling, Creutzberg Carien L, Smit Vincent T H B M
Abstract excerpt
PURPOSE: Recommendations for adjuvant treatment for women with early-stage endometrial carcinoma are based on clinicopathologic features. Comprehensive genomic characterization defined four subgroups: p53-mutant, microsatellite instability (MSI), POLE-mutant, and no specific molecular profile (NSMP). We aimed to confirm the prognostic capacity of these subgroups in large randomized trial populations, investigate...
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