Article
Low-Frequency Drug Resistance in HIV-Infected Ugandans on Antiretroviral Treatment Is Associated with Regimen Failure.
Antimicrobial agents and chemotherapy - 1 Jun 2016
Kyeyune Fred, Gibson Richard M, Nankya Immaculate, Venner Colin, Metha Samar, Akao Juliet, Ndashimye Emmanuel, Kityo Cissy M, Salata Robert A, Mugyenyi Peter, Arts Eric J, Quiñones-Mateu Miguel E
Abstract excerpt
Most patients failing antiretroviral treatment in Uganda continue to fail their treatment regimen even if a dominant drug-resistant HIV-1 genotype is not detected. In a recent retrospective study, we observed that approximately 30% of HIV-infected individuals in the Joint Clinical Research Centre (Kampala, Uganda) experienced virologic failure with a susceptible HIV-1 genotype based on standard Sanger sequencing....
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