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Article

Chelidonine selectively inhibits the growth of gefitinib-resistant non-small cell lung cancer cells through the EGFR-AMPK pathway.

Pharmacological research - 1 Sept 2020

Xie Ya-Jia, Gao Wei-Na, Wu Qi-Biao, Yao Xiao-Jun, Jiang Ze-Bo, Wang Yu-Wei, Wang Wen-Jun, Li Wei, Hussain Shahid, Liu Liang, Leung Elaine Lai-Han, Fan Xing-Xing

Abstract excerpt

Tyrosine kinase inhibitors (TKIs) have been widely used for the clinical treatment of patients with non-small cell lung cancer (NSCLC) harboring mutations in the EGFR. Unfortunately, due to the secondary mutation in EGFR, eventual drug-resistance is inevitable. Therefore, to overcome the resistance, new agent is urgently required. Chelidonine, extracted from the roots of Chelidonium majus, was proved to...

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Identifiers

PMID: 32464330
DOI: 10.1016/j.phrs.2020.104934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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