Article
Genetic Investigation of Complement Pathway Genes in Type 2 Diabetic Retinopathy: An Inflammatory Perspective.
Mediators of inflammation - 1 Jan 2016
Yang Ming Ming, Wang Jun, Ren Hong, Sun Yun Duan, Fan Jiao Jie, Teng Yan, Li Yan Bo
Abstract excerpt
Diabetic retinopathy (DR) has complex multifactorial pathogenesis. This study aimed to investigate the association of complement pathway genes with susceptibility to DR. Eight haplotype-tagging SNPs of SERPING1 and C5 were genotyped in 570 subjects with type 2 diabetes: 295 DR patients (138 nonproliferative DR [NPDR] and 157 proliferative DR [PDR]) and 275 diabetic controls. Among the six C5 SNPs, a marginal...
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