Article
Genome-wide association study in a Chinese population with diabetic retinopathy.
Human molecular genetics - 1 Aug 2013
Sheu Wayne H-H, Kuo Jane Z, Lee I-Te, Hung Yi-Jen, Lee Wen-Jane, Tsai Hin-Yeung, Wang J-S, Goodarzi Mark O, Klein Ronald, Klein Barbara E K, Ipp Eli, Lin Shin-Yi, Guo Xiuqing, Hsieh Chang-Hsun, Taylor Kent D, Fu Chia-Po, Rotter Jerome I, Chen Yii-Der I
Abstract excerpt
Diabetic retinopathy (DR) is a leading cause of preventable blindness in adults. To identify genetic contributions in DR, we studied 2071 type 2 diabetics. We first conducted a genome-wide association study of 1007 individuals, comparing 570 subjects with ≥8 years duration without DR (controls) with 437 PDR (cases) in the Chinese discovery cohort. Cases and controls were similar for HbA1c, diabetes duration and...
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