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Article

Selection at linked sites shapes heritable phenotypic variation in C. elegans.

Science (New York, N.Y.) - 15 Oct 2010

Rockman Matthew V, Skrovanek Sonja S, Kruglyak Leonid

Abstract excerpt

Mutation generates the heritable variation that genetic drift and natural selection shape. In classical quantitative genetic models, drift is a function of the effective population size and acts uniformly across traits, whereas mutation and selection act trait-specifically. We identified thousands of quantitative trait loci (QTLs) influencing transcript abundance traits in a cross of two Caenorhabditis elegans...

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Identifiers

PMID: 20947766
DOI: 10.1126/science.1194208
PMCID: PMC3138179

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