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Article

Lack of hippocampal CB1 receptor desensitization by Δ(9)-tetrahydrocannabinol in aged mice and by low doses of JZL 184.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Jun 2016

Feliszek Monika, Bindila Laura, Lutz Beat, Zimmer Andreas, Bilkei-Gorzo Andras, Schlicker Eberhard

Abstract excerpt

Activation of cannabinoid CB1 receptors may offer new therapeutic strategies, but the efficiency of CB1 receptor agonists may be impaired by tolerance development upon prolonged administration. We compared the influence of repeated administration of Δ(9)-tetrahydrocannabinol (THC) 10 mg/kg on the motility and on basal and CB1 receptor-stimulated (35)S-GTPγS binding of adolescent and aged mice. Moreover, we...

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Identifiers

PMID: 26984820
DOI: 10.1007/s00210-016-1226-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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