Article
Enhancement of Ebola Virus Infection via Ficolin-1 Interaction with the Mucin Domain of GP Glycoprotein.
Journal of virology - 1 Jun 2016
Favier Anne-Laure, Gout Evelyne, Reynard Olivier, Ferraris Olivier, Kleman Jean-Philippe, Volchkov Viktor, Peyrefitte Christophe, Thielens Nicole M
Abstract excerpt
UNLABELLED: Ebola virus infection requires the surface viral glycoprotein to initiate entry into the target cells. The trimeric glycoprotein is a highly glycosylated viral protein which has been shown to interact with host C-type lectin receptors and the soluble complement recognition protein mannose-binding lectin, thereby enhancing viral infection. Similarly to mannose-binding lectin, ficolins are soluble...
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