Article
Comparative analysis of human and mouse transcriptomes of Th17 cell priming.
Oncotarget - 22 Mar 2016
Tuomela Soile, Rautio Sini, Ahlfors Helena, Öling Viveka, Salo Verna, Ullah Ubaid, Chen Zhi, Hämälistö Saara, Tripathi Subhash K, Äijö Tarmo, Rasool Omid, Soueidan Hayssam, Wessels Lodewyk, Stockinger Brigitta, Lähdesmäki Harri, Lahesmaa Riitta
Abstract excerpt
Uncontrolled Th17 cell activity is associated with cancer and autoimmune and inflammatory diseases. To validate the potential relevance of mouse models of targeting the Th17 pathway in human diseases we used RNA sequencing to compare the expression of coding and non-coding transcripts during the priming of Th17 cell differentiation in both human and mouse. In addition to already known targets, several transcripts...
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