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Article

The High-Density Lipoprotein Puzzle: Why Classic Epidemiology, Genetic Epidemiology, and Clinical Trials Conflict?

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016

Rosenson Robert S

Abstract excerpt

Classical epidemiology has established the incremental contribution of the high-density lipoprotein (HDL) cholesterol measure in the assessment of atherosclerotic cardiovascular disease risk; yet, genetic epidemiology does not support a causal relationship between HDL cholesterol and the future risk of myocardial infarction. Therapeutic interventions directed toward cholesterol loading of the HDL particle have...

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PMID: 26966281
DOI: 10.1161/ATVBAHA.116.307024

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