Article
Paraconsistents artificial neural networks applied to the study of mutational patterns of the F subtype of the viral strains of HIV-1 to antiretroviral therapy.
Anais da Academia Brasileira de Ciencias - 1 Mar 2016
dos Santos Paulo C C, Lopes Helder F S, Alcalde Rosana, Gonsalez Cláudio R, Abe Jair M, Lopez Luis F
Abstract excerpt
The high variability of HIV-1 as well as the lack of efficient repair mechanisms during the stages of viral replication, contribute to the rapid emergence of HIV-1 strains resistant to antiretroviral drugs. The selective pressure exerted by the drug leads to fixation of mutations capable of imparting varying degrees of resistance. The presence of these mutations is one of the most important factors in the failure...
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