Article
A SOFM approach to predicting HIV drug resistance.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2002
Potter R Brian, Draghici Sorin
Abstract excerpt
The self-organizing feature map (SOFM or SOM) neural network approach has been applied to a number of life sciences problems. In this paper, we apply SOFMs in predicting the resistance of the HIV virus to Saquinavir, an approved protease inhibitor. We show that a SOFM predicts resistance to Saquinavir with reasonable success based solely on the amino acid sequence of the HIV protease mutation. The best single...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.