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Article

Altered ratios of pro‐ and anti‐angiogenic VEGF ‐A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma

9 Mar 2016

Abstract excerpt

Infantile haemangioma (IH), the most common neoplasm in infants, is a slowly resolving vascular tumour. Vascular endothelial growth factor A (VEGF-A), which consists of both the pro- and anti-angiogenic variants, contributes to the pathogenesis of IH. However, the roles of different VEGF-A variants in IH progression and its spontaneous involution is unknown. Using patient-derived cells and surgical specimens, we...

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Share to Vascular Malformations and Hemangiomas
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Identifiers

PMID: 26957058
DOI: 10.1002/path.4715

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