Article
The mdx Mutation in the 129/Sv Background Results in a Milder Phenotype: Transcriptome Comparative Analysis Searching for the Protective Factors.
PloS one - 1 Jan 2016
Calyjur Priscila Clara, Almeida Camila de Freitas, Ayub-Guerrieri Danielle, Ribeiro Antonio Fernando, Fernandes Stephanie de Alcântara, Ishiba Renata, Santos Andre Luis Fernandes Dos, Onofre-Oliveira Paula, Vainzof Mariz
Abstract excerpt
The mdx mouse is a good genetic and molecular murine model for Duchenne Muscular Dystrophy (DMD), a progressive and devastating muscle disease. However, this model is inappropriate for testing new therapies due to its mild phenotype. Here, we transferred the mdx mutation to the 129/Sv strain with the aim to create a more severe model for DMD. Unexpectedly, functional analysis of the first three generations of...
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