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Article

Modelling the PKPD of oxycodone in experimental pain - Impact of opioid receptor polymorphisms.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 30 Apr 2016

Olsen Rasmus, Foster David J R, Upton Richard N, Olesen Anne E, Ross Joy R, Droney Joanne, Sato Hiroe, Drewes Asbjørn M, Kreilgaard Mads

Abstract excerpt

BACKGROUND: Polymorphisms in the opioid receptor genes may affect the pharmacodynamics (PD) of oxycodone and be part of the reason behind the diversity in clinical response. The aim of the analysis was to model the exposure-response profile of oxycodone for three different pain variables and search for genetic covariates. Model simulations were used to predict how population and effect-size impact the power to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26946441
DOI: 10.1016/j.ejps.2016.02.021

Genes

OPRK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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